Project information
Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches (EPICARD)

Information

This project doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

2B08060

Project Period

3/2008 - 12/2011

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

Health and quality of life

MU Faculty or unit

Central European Institute of Technology

prof. RNDr. Zbyněk Zdráhal, Dr.

Keywords

Cardiovascular disorders, familial hypercholesterolemia, LDL receptor, cholesterol, aortic valve calcification, NOTCH1, DNA microarray, chromatin immunoprecipitation, real-time PCR, epigenetics, posttranslational modifications, mass spectrometry

Cooperating Organization

Centre for Cardiovascular and Transtplantation Surgary

Responsible person prof. MUDr. Tomáš Freiberger, Ph.D.

University Hospital Brno-Bohunice

Responsible person doc. RNDr. Lenka Fajkusová, CSc.

The aim of the project is to introduce novel molecular-genetic, genomic and proteomic approaches in diagnostics of serious heart and vascular diseases.

Publications

Total number of publications: 20

2011

Spectrum of CLCN1 and SCN4A mutations in Czech patients with non-dystrophic myotonias.

PÁCLOVÁ Daniela SEDLÁČKOVÁ Jana VOHÁŇKA Stanislav MAZANEC FAJKUSOVÁ Lenka

Conference abstract

Year: 2011, type: Conference abstract
Spectrum of point mutations in Czech DMD/BMD patients and their phenotypic outcome

ZAPLETALOVÁ Eva SEDLÁČKOVÁ Jana HERMANOVÁ M. ZÁMEČNÍK J. FAJKUSOVÁ Lenka

Conference abstract

Year: 2011, type: Conference abstract
The molecular diagnostics of familial hypercholesterolemia in Czech Republic.

TICHÝ Lukáš ZAPLETALOVÁ Petra ZAPLETALOVÁ Eva STEHLÍKOVÁ Kristýna LETOCHA Ondřej PORUPKOVÁ Jitka FREIBERGER Tomáš FAJKUSOVÁ Lenka

Conference abstract

Year: 2011, type: Conference abstract

2010

Analýza sekvenčních změn v LDLR genu: od mutací k rozsáhlým přestavbám a zpět

TICHÝ Lukáš DUŠKOVÁ Lucie ZAPLETALOVÁ Petra KOPEČKOVÁ Lenka LETOCHA Ondřej FAJKUSOVÁ Lenka

Conference abstract

Year: 2010, type: Conference abstract
Detection of Cardiobacterium valvarum in patient with aortic valve infective endocarditis by broad-range PCR.

VANĚRKOVÁ Martina ŽALOUDÍKOVÁ Barbora NĚMCOVÁ Eva JURÁNKOVÁ Jana POL Jiří ČERNÝ Jan NĚMEC Petr FREIBERGER Tomáš

Article in Periodical

Journal of Medical Microbiology, year: 2010, volume: 59, edition: 2
Familial Hypercholesterolemia in the Czech republic

TICHÝ Lukáš STEHLÍKOVÁ Kristýna ZAPLETALOVÁ Petra DUŠKOVÁ Lucie KOPEČKOVÁ Lenka FREIBERGER Tomáš FAJKUSOVÁ Lenka

Conference abstract

Year: 2010, type: Conference abstract
Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia

GOLDMANN Radan TICHÝ Lukáš FREIBERGER Tomáš ZAPLETALOVÁ Petra LETOCHA Ondřej SOŠKA Vladimír FAJKUS Jiří FAJKUSOVÁ Lenka

Article in Periodical

BMC Medical Genetics, year: 2010, volume: 11, edition: 115
CHARACTERISATION OF HUMAN HISTONE N TERMINAL ACETYLATIONS

NOVÁKOVÁ Kateřina ČINČÁROVÁ Lenka FAJKUSOVÁ Lenka FAJKUS Jiří ZDRÁHAL Zbyněk

Conference abstract

Year: 2010, type: Conference abstract
Výsledky molekulárně genetického vyšetření pacientů Dětské lipidové poradny Fakultní nemocnice Olomouc v rámci projektu MedPed

HYJÁNEK J. PASTUCHA D. TICHÝ Lukáš FAJKUSOVÁ Lenka FREIBERGER Tomáš

Article in Periodical

Česko - Slovenská Pediatrie, year: 2010, volume: 65, edition: 7-8
Využití DNA čipu v molekulárně genetické diagnostice familiární hypercholesterolémie

KOPEČKOVÁ Lenka GOJOVÁ Lucie JANSOVÁ Eva GOLDMANN Radan ZAPLETALOVÁ Petra FREIBERGER Tomáš FAJKUSOVÁ Lenka

Year: 2010, type: