Project information
Advanced sequencing methods for deciphering structural variants in cancer genome
- Project Identification
- NU21-08-00237
- Project Period
- 5/2021 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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University Hospital Brno-Bohunice
Moderní metody sekvenování DNA umožňují podrobné mapování nádorového genomu a identifikaci lézí, na něž je možné cílit protinádorovou léčbu. Sekvenování pomocí dlouhého čtení dovoluje charakterizovat přestavby genomu, které je obtížné přesně určit pomocí standardních metod nádorové cytogenetiky. Ve skupině pacientů s hematoonkologickými diagnózami chceme využít nové sekvenační metody pro zjištění organizace genomu a rekurentních přestaveb s cílem pochopit mechanismy vzniku aberací a určit jejich význam pro klinický průběh nemoci a odpověď na léčbu.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 43
2022
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Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage
Year: 2022, type: Conference abstract
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Distinct p53 phospohrylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage.
Year: 2022, type: Conference abstract
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Driver genes for chronic lymphocytic leukemia can be affected not only by mutations but also by complex genomic rearrangements.
Year: 2022, type: Conference abstract
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Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations
Frontiers in Oncology, year: 2022, volume: 12, edition: June 2022, DOI
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Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
BMC Cancer, year: 2022, volume: 22, edition: 1, DOI
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Exploring clonal evolution in CLL: Analysis by whole exome sequencing.
Year: 2022, type: Conference abstract
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Exploring different aspects of clonal evolution in chronic lymphocytic leukemia
Year: 2022, type: Conference abstract
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In-frame deletions and insertions in the TP53 gene identified in leukemia patients result in p53 protein inactivation.
Year: 2022, type: Conference abstract
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Long-read whole genomes sequencing used to detect complex chromosomal rearrangements
Year: 2022, type: Conference abstract
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LYNX: A web-based bioinformatic tool for targeted next-generation sequencing data analysis and visualization in lymphoid malignancies.
Year: 2022, type: Conference abstract