Origin and evolution of genes and genomes. Crucial role of triplet expansions

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Authors	TRIFONOV Eduard Nikolajevič FRENKEL Zakharia M
Year of publication	2012
Type	Article in Periodical
Magazine / Source	J. Biomol. Struct. Dynamics 12
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.677771
Doi	http://dx.doi.org/10.1080/07391102.2012.677771
Field	Genetics and molecular biology
Keywords	triplet expansion; repeats; codon usage; gene evolution
Description	A novel concept on mechanisms of evolution of genes and genomes is suggested: the sequences evolve largely by local events of triplet expansion and subsequent mutational changes in the repeats.Life which, presumably, started with replication of expanding triplets and their subsequent mutational changes, is continuing to emerge within the genes and genomes, in form of new events of triplet expansion.
Related projects:	CHROMPLANT CEITEC - Central European Institute of Technology