Vliv proteinů Fos na růst a diferenciaci monoblastů transformovaných onkogenem v-myb

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Title in English	The effects of Fos proteins on growth and differentiation of v-myb-transformed monoblasts
Authors	ZAHRADNÍČKOVÁ Eva ŠEVČÍKOVÁ Sabina SOUČEK Karel ŠMARDA Jan
Year of publication	2001
Type	Article in Proceedings
Conference	XVI. Biologické dny
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Fos
Description	Fos proteins participate in formation of AP-1 transcription factor, that is significantly involved in regulation of proliferation and differentiation of various cell types. The line of v-myb-transformed chicken monoblasts BM2 belongs is potentially sensitive to the level and activity of Fos proteins. To investigate the effects of Fos proteins on growth and differentiation of BM2 cells, we prepared the BM2 cell line variants inducibly expressing c-fos and v-fos genes. We showed that both Fos variants decrease proliferation of BM2 cells. Interestingly, mechanisms of the effects induced by cellular and viral Fos forms seems to be different. While c-Fos increases frequency of cell death by apoptosis, v-Fos protein does not. On the other hand, v-Fos and in less extent also c-Fos induces dedifferentiation of BM2 cells.
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