Neurobiologie hyperkinetické poruchy
| Title in English | Neurobiology of ADHD |
|---|---|
| Authors | |
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | ADHD; hyperkinetic disorder; association study; polymorphism; gene; DRD2; DRD4; COMT; DBH; DAT1; NET1; MAO; IL-6 |
| Description | Attention-deficit hyperactivity disorder (ADHD) belongs to common causes of psychiatric treatment in childhood. Risk factors of the pathogenesis are not only genetic factors, but also non-genetic ones such as low weight at birth, perinatal hypoxia and influence of toxic substancies during the prenatal period. The causes of the disorder have been thoroughly investigated using the neuroimaging and molecular biology methods in the past ten years. It was found that biological parents and relatives with ADHD have much higher percentage of ADHD symptoms in their offsprings. Obviously, the results of twin studies have brought the evidence of the disorders heritability. During the past few years many molecular-biology studies have appeared, which are focused on the research of influence of so-called candidate genes in the pathogenesis of ADHD. Our review summarises the results of these studies. |
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