Trapped water molecules are essential to structural dynamics and function of a ribozyme
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | The Proceedings of the National Academy of Sciences |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire |
| Description | Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network. |
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