Synthesis and reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates

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Authors	PAZDERA Pavel MOHAMED Walid Fathalla
Year of publication	2007
Type	Article in Periodical
Magazine / Source	ARKIVOC
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	Non-nucleoside RT inhibitors; quinazoline; thioureas; amino acids; imidoyl isothiocyanate; Domino-reaction; intramolecular cyclization
Description	Methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates bearing an amino acid ester residue were prepared by a novel three step sequential reaction of N-(2-cyanophenyl)benzimidoyl isothioyanate with amino acid methyl ester hydrochlorides. Some chemoselective reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates with alkyl halides were studied.
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