Synthesis and structure_activity relationship studies of theophylline analogs

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Authors	ANANTHALAKSHMI Kethireddy V. V. BARTL Tomáš AZIZA Mohammed H. NOVOTNÝ Ladislav MAREK Radek BENEŠ Luděk KOMBIAN Samuel B.
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Bioorganic & Medicinal Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Biochemistry
Keywords	Hippocampus; Acetylcholine receptors; Dementia; Nootropic; Theophylline analogs
Description	We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre