C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions

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Authors	KADEŘÁVEK Pavel FIALA Radovan
Year of publication	2008
Type	Article in Proceedings
Conference	XXIII International Conference on Magnetic Resonance in Biological Systems
MU Faculty or unit	Faculty of Science
Citation
Field	Biophysics
Keywords	NMR; nucleic acids;RNA;dynamics
Description	NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre