Relationships between levels of methylated arginine (ADMA), genetic variability of the reninangiontensin system and diabetic kidney disease
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| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | L arginine and ADMA can both affect production of NO (regulation of renal hemodynamics). However, recent studies indicated that rather than inhibition of NO production by ADMA, pathologic activation of RAS and subsequent increase of oxidative stress (ACE ATIIR1 NAD(P)H oxidase pathway) play more significant pathogenic role. The aim of the study was to investigate i) relationship between plasma levels of L arginine and ADMA and stage of diabetic kidney disease and ii) relationship between ADMA, genetic variability in the RAS and stages of diabetic nephropathy. Significant correlation between the stage of kidney disease and L arginine (negative) and ADMA (positive) was ascertained (P < 0.05, Spearman). ADMA significantly correlated with both components of diabetic kidney disease, i.e. proteinuria and GFR (P < 0.05, Spearman). Multiple regression identified ADMA however, none of the RAS polymorphisms analysed, as a significant predictor of renal outcome (P < 0.01). |
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