Novel  fucose binding lectin domain from the human pathogen Bukholderia cenocepacia

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Authors	ŠULÁK Ondřej CIOCI Gianluca DELIA Monia IMBERTY Imberty WIMMEROVÁ Michaela
Year of publication	2009
Type	Article in Proceedings
Conference	Glycoconjugate Journal
MU Faculty or unit	Faculty of Science
Citation
Field	Biochemistry
Keywords	Superlectin; X ray; Isothermal titration callorimetry; Burkolderia cenocepacia
Description	The contribution is focused on the BclC lectin that displays affinity for both fucosylated and mannosylated saccharides. Separate cloning of N- and C terminal parts of the protein showed that while C-terminal part, which is homologous to PA-IIL, displays narrow specificity for mannosylated oligosaccharides, N-terminal part represent a novel lectin domain with strict specificity towards fucosylated oligosaccharides.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biomolecular centre Molecular mechanisms of the cell proliferation and differentiation Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs Lectins from human pathogens - structure, function, engineering