Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex

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Authors	KUBÍČEK Karel MONNET Jordan SCINTILLA Simone KOPEČNÁ Jana ARNESANO Fabio TRANTÍREK Lukáš CHOPARD Claude NATILE Giovanni KOZELKA Jiří
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Chemistry - An Asian Journal
MU Faculty or unit	Faculty of Science
Citation
Web	http://dx.doi.org/10.1002/asia.200900655
Field	Biophysics
Keywords	DNA structures; interstrand crosslinks; molecular modeling; NMR spectroscopy; platinum
Description	An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-di-aminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA.
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