| Description |
The goal of the study was an analysis of the influence of conventional as well as new prognostic factors on overall surfoval (OS) of CLL patients. We retrospectively analyzed data of patients entered into the databáze of four hematological center. Monitored parameters were clinical stage, age, gender, status IgVh gene mutation, deletion 17p, deletion 11q, trisomy 12, deletion 13q, CD38, ZAP-70. The analysis of individual influence of each factor on OS, as well as multiparametric analysis of prognostic factors were performed. The total of 1146 patients (median age 61years, 32-90, sex: 707 male, 439 female) underwent the analysis. Through the use of uniparametric analysis, it was determined that advanced stage of CLL (Rai II IV) (p menší než 0,001), unmutated IgVh status (p menší než 0,001), deletion 17p (p menší než 0,001) and increased expression of CD38 (p=0,01) had significant negative influence on OS. Multiparametric analysis revealed that OS was significantly influenced by gender (men with CLL have approximately three times higher risk of death than women, p=0,02), age (p=0,04), IgVh status (p=0,03) and deletion 17p (p=0,007).
|