Molecular Typing of Syphilis-Causing Strains Among Human Immunodeficiency Virus-Positive Patients in Antwerp, Belgium

• Autoři: MIKALOVÁ Lenka; GRILLOVÁ Linda; OSBAK Kara; STROUHAL Michal; KENYON Chris; CRUCITTI Tania; ŠMAJS David
• Rok publikování: 2017
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Sexually Transmitted Diseases
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.1097/OLQ.0000000000000600
• Obor: Genetika a molekulární biologie
• Klíčová slova: Treponema pallidum
• Popis: Centers for Disease Control and Prevention and sequencing-based treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency virus and syphilis co-infected patients during 2014 to 2015 in Antwerp, Belgium. Twenty-nine (40.3%) isolates were polymerase chain reaction positive for Treponema pallidum, and all tested were macrolide-resistant. Four genotypes were identified by sequencing-based typing including two new genotypes, U4NR8 and SU9R8, whereas enhanced Centers for Disease Control and Prevention typing revealed 7 subtypes.

Související projekty

• Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema
• Genomová variabilita treponem během experimentální infekce