Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
| Autoři | |
|---|---|
| Rok publikování | 2025 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Angewandte Chemie International Edition |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754 |
| Doi | http://dx.doi.org/10.1002/anie.202424754 |
| Klíčová slova | Supramolecular Chemistry; Anion transport; Anion Channels; Macrocycles; Bambusurils |
| Přiložené soubory | |
| Popis | Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane. |
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