Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 142
2025
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Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
Angewandte Chemie International Edition, rok: 2025, ročník: 64, vydání: 9, DOI
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RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome
Nature Communications, rok: 2025, ročník: 16, vydání: 1, DOI
2024
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MoaB2, a newly identified transcription factor, binds to σA in Mycobacterium smegmatis
Journal of Bacteriology, rok: 2024, ročník: 206, vydání: 12, DOI
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Proteogenomic Classification of Triple-Negative Breast Cancer for Prognosis and Targeted therapy
Rok: 2024, druh: Konferenční abstrakty
2023
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A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody
Cell Reports, rok: 2023, ročník: 42, vydání: 9, DOI
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Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning
ACS Catalysis, rok: 2023, ročník: 13, vydání: 19, DOI
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Asymmetric Hydroxymethylation of Isoindolinones Using Bench-Stable Formaldehyde Surrogates
Rok: 2023, druh: Další prezentace na konferencích
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Cardiovascular Diseases
Mechanics in Diseased Cells and Tissues, Volume 2 Biomedical Applications, rok: 2023, počet stran: 26 s.
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Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules
Angewandte Chemie International Edition, rok: 2023, ročník: 62, vydání: 1, DOI
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De novo design of peptides that form transmembrane barrel pores killing antibiotic resistant bacteria
Rok: 2023, druh: Konferenční abstrakty