Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 239
2018
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Practical Workshop on Cryo-electron Microscopy Data Analysis in Scipion
Rok: 2018, druh: Uspořádání workshopu
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Preparation of Heteroleptic Tin(IV) N,O-beta-heteroarylalkenolate Complexes and Their Properties as PI-MOCVD Precursors for SnO2 Deposition
European Journal of Inorganic Chemistry, rok: 2018, ročník: 46, vydání: DEC 13 2018, DOI
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Protein environment affects the water-tryptophan binding mode. MD, QM/MM, and NMR studies of engrailed homeodomain mutants
Physical Chemistry Chemical Physics, rok: 2018, ročník: 20, vydání: 18, DOI
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Proteomic characterization and antifungal activity of potato tuber proteins isolated from starch production waste under different temperature regimes
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, rok: 2018, ročník: 102, vydání: 24, DOI
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Proteomics practical course for MSc students
Rok: 2018, druh: Uspořádání workshopu
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Prussian Blue Nanoparticles as a Catalytic Label in a Sandwich Nanozyme-Linked Immunosorbent Assay
Analytical Chemistry, rok: 2018, ročník: 90, vydání: 3, DOI
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Rapid identification of Intact staphylococcal bacteriophages using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
VIRUSES-BASEL, rok: 2018, ročník: 10, vydání: 4, DOI
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Role of SH3b binding domain in a natural deletion mutant of Kayvirus endolysin LysF1 with a broad range of lytic activity
Virus Genes, rok: 2018, ročník: 54, vydání: 1, DOI
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RS20L protein from bacterium Ralstonia solanacearum : Studies of lectin activity and oligomerization
Rok: 2018, druh: Konferenční abstrakty
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Selectivity of original C-hexopyranosyl calix[4]arene conjugates towards lectins of different origin
Carbohydrate Research, rok: 2018, ročník: 469, vydání: NOV, DOI