Project information
Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease progress
- Project Identification
- NV19-03-00091
- Project Period
- 5/2019 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2015 - 2022
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person Mgr. Veronika Navrkalová, Ph.D.
Chronic lymphocytic leukemia (CLL) is common and still incurable leukemia of adults characterized by remarkable genetic and clinical heterogeneity. In proposed project we aim to study genetic background underlying clonal evolution of genomic alterations in treatment naïve CLL patients taking the advantage of availability of consecutive samples collected during disease course. Our main objective is to early disclose the disease progression and therapy need. We plan to assess both the prognostic and the predictive value of genomic aberrations detected just before treatment start. For this purpose, a highly complex next-generation sequencing (NGS) tool analyzing simultaneously both fundamental, as well as novel CLL biomarkers will be implemented. We employ benefits of capture-based NGS technology enabling to analyze in one test IGHV mutational status, recurrent chromosomal and gene defects, and Ig light chains clonality. We presume that our NGS panel tailored for CLL can be widely adopted in clinical practice as a simple comprehensive test for better patient prognostication.
Publications
Total number of publications: 46
2020
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Minor-clone TP53 mutations in CLL patients entering first-line treatment: clonal evolution and clinical impact.
Year: 2020, type: Conference abstract
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Panel sond pro detekci prognostických a prediktivních markerů lymfoproliferativních onemocnění
Year: 2020
2019
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Biologická a klinická analýza souboru nemocných s refrakterní a relabující chronickou lymfocytární leukémií
Year: 2019, type: Conference abstract
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LYNX (Lymphoid NGS): Komplexní NGS panel pro analýzu prognostických a prediktivních markerů B-buněčných lymfoprolyferací.
Year: 2019, type: Conference abstract
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Nádorová cytogenetika 20 a 21.století: Od konvenční cytogenetiky k „next-generation“ cytogenetice hematologických malignit
Year: 2019, type: Conference abstract
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Srovnání počtu a alelické četnosti mutací genu TP53 u pacientů před první terapií a pacientů s relabující/refrakterní chronickou lymfocytární leukemií.
Year: 2019, type: Conference abstract