Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 251
2017
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Summer school in new approaches in experimental biology and omics
Rok: 2017, druh: Uspořádání workshopu
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Supramolecular Storage and Controlled Photorelease of an Oxidizing Agent using a Bambusuril Macrocycle
Chemistry - A European Journal, rok: 2017, ročník: 23, vydání: 66, DOI
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Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness
Biochimica et Biophysica Acta - Proteins and Proteomics, rok: 2017, ročník: 1865, vydání: 5, DOI
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The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer
COLLOID AND POLYMER SCIENCE, rok: 2017, ročník: 295, vydání: 1, DOI
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The first C(O)NHP(O)-based phosphoric triamide structure with an N-H...pi hydrogen bonding: A combination of X-ray crystallography and theoretical study to evaluate the strength of hydrogen bonds
Phosphorus, Sulfur, and Silicon and the related elements, rok: 2017, ročník: 192, vydání: 8, DOI
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Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia
Carbohydrate Research, rok: 2017, ročník: 437, vydání: January 2017, DOI
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Triple resonance NMR relaxation experiments for studies of intrinsically disordered proteins
Journal of Biomolecular NMR, rok: 2017, ročník: 69, vydání: 3, DOI
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Variations of Histone Modification Patterns: Contributions of Inter-plant Variability and Technical Factors
Frontiers in Plant Science, rok: 2017, ročník: 8, vydání: 2084, DOI
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Virion Structure of Black Queen Cell Virus, a Common Honeybee Pathogen
JOURNAL OF VIROLOGY, rok: 2017, ročník: 91, vydání: 6, DOI
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Visualization of stable ferritin complexes with palladium, rhodium and iridium nanoparticles detected by their catalytic activity in native polyacrylamide gels
Dalton Transactions, rok: 2017, ročník: 46, vydání: 40, DOI